KMID : 1036920140190020091
|
|
Annals of Pediatric Endocrinology & Metabolism 2014 Volume.19 No. 2 p.91 ~ p.95
|
|
Associations between serum vitamin D levels and precocious puberty in girls
|
|
Lee Hae-Sang
Kim You-Jin Shim Young-Seok Jeong Hwal-Rim Kwon Eun-Byul Hwang Jin-Soon
|
|
Abstract
|
|
|
Purpose: Vitamin D deficiency has been linked to chronic diseases, such as diabetes mellitus, obesity and autoimmune disease. However, data on the vitamin D status and its association with precocious puberty in girls are limited. We aimed to investigate the association between serum 25-hydroxyvitamin D (25OHD) and precocious puberty in girls.
Methods: A total of 60 girls with central precocious puberty (CPP) and 30 control girls were enrolled. Anthropometric measurement and serum level of 25OHD were estimated for all subjects.
Results: There was a significant difference in the mean serum 25OHD concentration between the precocious puberty group and the control group (17.1¡¾4.5 ng/mL vs. 21.2¡¾5.0 ng/mL, P<0.05). Forty-two of the 60 girls with CPP (70%) had vitamin D deficiency (defined as serum 25OHD<20 ng/mL) and 18 (30%) had vitamin D insufficiency. Of the 30 girls in the control group, vitamin D deficiency was seen in 13 subjects (43.3%), 15 subjects (50%) had vitamin D insufficiency, and 2 subjects (6.7%) had sufficient serum vitamin D (defined as serum 25OHD>30 ng/mL). Vitamin D deficient girls had a significantly higher odds ratio (OR, 3.05; 95% CI, 1.22-7.57, P=0.021).
Conclusion: These results showed that vitamin D levels may be associated with precocious puberty. Further studies are required to establish the potential effect of vitamin D status on puberty.
|
|
KEYWORD
|
|
Vitamin D, Precocious puberty, Female
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|